Process for the preparation of conjugates in which a...

Details Process for the preparation of conjugates in which a... Process for the preparation of conjugates in which a...

A - Human Necessities

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195/1.11

A61K 47/00 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07D 407/04 (2006.01) C07H 19/00 (2006.01) C07H 19/01 (2006.01)

Patent

CA 1314245

IN THE CANADIAN PATENT & TRADEMARK OFFICE PATENT APPLICATION entitled: Process for the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, which are useful as immunotoxin potentiators. in the names of: Franz K. JANSEN Pierre GROS Assignee: Société anonyme styled: SANOFI ABSTRACT OF THE DISCLOSURE The present invention relates to the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule chosen from antibodies, fragments of antibodies, proteins such as peptide hormones or human proteins, and peptide ligands. These conjugates are suitable as immunotoxin potentiators.

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