Process for the preparation of contrast agents

Details Process for the preparation of contrast agents Process for the preparation of contrast agents

C - Chemistry, Metallurgy

07

C

C07C 227/08 (2006.01) C07C 229/22 (2006.01)

Patent

CA 2621339

The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques.

La présente invention concerne un procédé de synthèse d'un composé de formule (I) par réaction de carboxyméthylation en présence d'un agent d'alkylation adapté et d'une base, sans qu'il soit nécessaire de surveiller le pH du milieu réactionnel. Le composé de formule (I) est un intermédiaire pouvant être employé dans la synthèse d'agents de contraste utilisables en diagnostic dans les techniques d~IRM.

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