Process for the preparation of copolymer-1

Details Process for the preparation of copolymer-1 Process for the preparation of copolymer-1

C - Chemistry, Metallurgy

08

G

C08G 69/48 (2006.01) C08G 69/04 (2006.01) C08G 69/08 (2006.01)

Patent

CA 2619123

Copolymer-1 is a mixture of synthetic polypeptides composed of alanine, glutamic acid, lysine, and tyrosine. The invention relates to an improved process for the preparation of copolymer-1 characterized by the deblocking of the protected copolymer-1 that is carried out in one reaction. The process of the present invention has the advantage of high yield and ease of production. Copolymer-1 is a useful drug in treating multiple sclerosis.

Un copolymère-1 est un mélange de polypeptides synthétiques composé d'alanine, d'acide glutamique, de lysine et de tyrosine. L'invention concerne un procédé amélioré destiné à la préparation d'un copolymère-1, se caractérisant par le fait que le déblocage du copolymère-1 protégé se fait en une étape de réaction. Le procédé de la présente invention permet d'obtenir un rendement élevé et de faciliter la production. Le copolymère-1 est un médicament pouvant être utilisé pour le traitement de la sclérose en plaques.

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