Process for the preparation of crystalline monohydrate of...

Details Process for the preparation of crystalline monohydrate of... Process for the preparation of crystalline monohydrate of...

C - Chemistry, Metallurgy

07

D

260/104.5

C07D 501/22 (2006.01) A61K 31/545 (2006.01)

Patent

CA 1115268

ABSTRACT This invention relates to an improved process for preparing the cephalosporin compound 7-[D-.alpha.-amino-.alpha.-(p- hydroxyphenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acid which is disclosed and claimed in U.K. Patent 1,240,687. The above-named compound has been given the generic name cefadroxil and has the structural formula Image Also provided by the present invention are a novel crystalline monohydrate of cefadroxil and processes for preparing said monohydrate. Cefadroxil (including pharmaceutically acceptable salts thereof and especially the new crystalline monohydrate form) is active as a broad spectrum antibiotic effective in controlling diseases caused by a wide variety of Gram-positive and Gram-negative microorganisms. It is of particular interest as an oral cephalosporin antibiotic.

276959

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