Process for the preparation of derivatives of 2-...

C - Chemistry – Metallurgy – 07 – C

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260/479.4

C07C 219/12 (2006.01)

Patent

CA 1214470

ABSTRACT Pharmaceutically acceptable salts of 2- diethylarnino-l-methylethyl cis-l-hydroxy-(bicyclohexyl)- 2-carboxylate, particularly the citrate, maleate, fumarate and pamoate, are prepared from the phosphate of 2-diethylamino-1-methylethyl cis-l-hydroxy (bi- cyclohexyl)-2-carboxylate, whereby solid products are obtained, which are either soluble in water for readily absorbable preparations or poorly soluble for delayed release compositions.

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