Process for the preparation of derivatives of 4,...

Details Process for the preparation of derivatives of 4,... Process for the preparation of derivatives of 4,...

C - Chemistry, Metallurgy

07

D

167/231, 260/277

C07D 413/14 (2006.01) A61K 31/44 (2006.01) C07D 495/04 (2006.01)

Patent

CA 1256109

Abstract of the disclosure The invention relates to a process for the prep- aration of novel derivatives of 4,5-dihydrooxazoles of the formula I Image I in which A denotes -CH=CH- or -S-, R1, R3 and R4, independently of one another, denote hydrogen or lower alkyl, R2 denotes hydrogen or lower alkoxy, and n denotes 0 or 1, in which a compound of the formula II Image II in which A has the meaning given in formula I, is reacted with a compound of the formula III III Image in which X represents chlorine or bromine and R1, R2, R3 and R4 have the meaning given in formula I, in the presence of a strong base, and the product is subsequently oxidized, if appropriate, to form a sulfoxide. The compounds of the formula I cause a blockage of H+/K+-ATPase and thereby have a gastric secretion-inhibiting action.

546073

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