Process for the preparation of dihaloazolopyrimidines

Details Process for the preparation of dihaloazolopyrimidines Process for the preparation of dihaloazolopyrimidines

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01)

Patent

CA 2188905

An effective and efficient process for the preparation of a dihaloazolopyrimidine having the structural formula (see formula I) In this process, a malonic acid ester is reacted with a heterocyclylamine to form an intermediate salt, which optionally may be acidified to form a dihydroxyazolopyrimidine; the salt or the dihydroxyazolopyrimidine is then halogenated.

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