C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 17/06 (2006.01) C07C 67/03 (2006.01) C07D 319/06 (2006.01) C12P 7/62 (2006.01) C07C 69/716 (2006.01) C12N 9/20 (2006.01)
Patent
CA 2677945
A process is provided for the preparation of a compound of formula (1) (see formula 1) wherein R and R' represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.
Blacker Andrew John
Holt Robert Antony
Reeve Christopher David
Astrazeneca Uk Limited
Smart & Biggar
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