Process for the preparation of dispersible colloidal systems...

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B01J 13/02 (2006.01) A61K 9/51 (2006.01) C08J 3/14 (2006.01)

Patent

CA 1292168

PV/JL-F257 Process for the preparation of dispersible colloidal systems of a substance in the form of nanoparticles ABSTRACT OF THE TECHNICAL CONTENT OF THE INVENTION The process according to the invention comprises: (1) the preparation of a liquid phase consisting essentially of a solution of the substance in a solvent or in a mixture of solvents to which may be added one or more surfactants, (2) the preparation of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the substance and to which may be added one or more surfactants, the non-solvent or the mixture of non- solvents for the substance being miscible in all proportions with the solvent or the mixture of solvents for the substance, (3) the addition of one of the liquid phases prepared in (1) or (2) to the other with moderate stirring so as to produce a colloidal suspension of nano- particles of the substance and, (4) if desired, the removal of all or part of the solvent or the mixture of solvents for the substance and of the non-solvent or the mixture of non- solvents for the substance so as to produce a colloidal suspension of nano- particles of the desired concentration or to produce a powder of nano- particles. Applications: Chemistry, biochemistry, pharmacy, medicine. No figures.

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