B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
167/163, 134/41
B01J 13/02 (2006.01) A61K 9/51 (2006.01)
Patent
CA 1293170
Process for the preparation of dispersible colloidal systems of a substance in the form of nanocapsules ABSTRACT OF THE TECHNICAL CONTENT OF THE INVENTION The process according to the invention comprises: (1) the preparation of a liquid phase consisting essentially of a solution of a substance A in a solvent or in a mixture of solvents, and containing the substance B in solution or as a dispersion, (2) the preparation of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the substances A and B, and supplemented with one or more surfactants, the solvent or mixture of solvents of the first phase being miscible in all proportions with the non- solvent or mixture of non-solvents of the second phase, (3) the addition of the first phase to the second phase with moderate agitation so as to produce a colloidal suspension of nanocapsules, the wall of which is constituted by the substance A and the core by the substance B, (4) if desired, the removal of all or part of the solvent or the mixture of solvents and of the non-solvent or the mixture of non-solvents so as to produce a colloidal suspension of nanocapsules of the desired concentration or to produce a powder of nanocapsules following the addition of stabilizing substances. Applications: chemistry, biochemistry, pharmacy, medicine. No figures.
555153
Devissaguet Jean-Philippe
Fessi Hatem
Puisieux Francis
Centre National de La Recherche Scientifique (c.n.r.s.)
Goudreau Gage Dubuc
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