Process for the preparation of drospirenone

Details Process for the preparation of drospirenone Process for the preparation of drospirenone

C - Chemistry, Metallurgy

07

J

C07J 53/00 (2006.01) A61K 31/585 (2006.01) A61P 15/18 (2006.01) C07J 21/00 (2006.01)

Patent

CA 2589928

A process is described for the preparation of drospirenone, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for preparing pharmaceutical compositions with contraceptive action; comprising the oxidation of 17.alpha.-(3-hydroxypropyl)-6.beta., 7.beta., 15.beta., 16.beta.-dimethylene-5.beta.-androstane- 3.beta. , 5, 17.beta. - triol.

L'invention porte sur un procéder de préparation de la drospirénone, sur stéroïde synthétique ayant une activité progestogénique, antiminéralocorticoïde et antiandrogénique, et utile dans la préparation de compositions pharmaceutiques à action contraceptive. Ce procédé comprend l'oxydation de 17a-(3-hydroxypropyl)-6ß, 7ß, 15ß, 16ß-diméthylène-5ß-androstane- 3ß, 5, 17ß -triol.

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