Process for the preparation of duloxetine

Details Process for the preparation of duloxetine Process for the preparation of duloxetine

C - Chemistry, Metallurgy

07

D

C07D 333/20 (2006.01)

Patent

CA 2626500

The invention relates to a process for the preparation of duloxetine (1a), comprising the reaction between 1-fluoronaphthalene and 3-N,N-dimethylamino-l- (2-thienyl)-propan-l-ol in the presence of l,3-dimethyl-2-oxo- hexahydropyrimidine (DMPU) as the solvent; a method for the identification of duloxetine enantiomers and for the determination of its optical purity is also disclosed.

L'invention concerne un procédé de fabrication de duloxétine 1a, comprenant la réaction entre le 1-fluoronaphthalène et le 3-N,N-diméthylamino-1-(2-thiényl)-propan-1-ol en présence de 1,3-diméthyl-2-oxo-hexahydropyrimidine (DMPU) en tant que solvant ; ainsi qu~un procédé d~identification d~énantiomères de duloxétine et de détermination de sa pureté optique.

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