Process for the preparation of enantiomeri cally enriched...

Details Process for the preparation of enantiomeri cally enriched... Process for the preparation of enantiomeri cally enriched...

C - Chemistry, Metallurgy

12

P

C12P 13/00 (2006.01) C12P 13/06 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2648697

The invention relates to a process for the preparation of an enantiomerically enriched .beta.-amino alcohol, wherein glycine or a glycine salt and an aldehyde are reacted in the presence of a threonine aldolase and a decarboxylase to form the corresponding enantiomerically enriched .beta.-aminoalcohol, and wherein at least either the threonine aldolase or the decarboxylase is .beta.-selective. In a preferred embodiment of the invention at least either the threonine aldolase or the decarboxylase is enantioselective.

La présente invention concerne un procédé de préparation d'un .beta.-aminoalcool enrichi sur le plan énantiomérique, ledit procédé impliquant de faire réagir de la glycine ou un sel de glycine avec un aldéhyde, en présence d'une thréonine aldolase et d'une décarboxylase, de manière à former le .beta.-aminoalcool correspondant enrichi sur le plan énantiomérique, au moins ladite thréonine aldolase ou décarboxylase étant .beta.-sélective. Sous l'un des modes de réalisation de l'invention préféré, au moins la thréonine aldolase ou la décarboxylase est énantiosélective.

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