Process for the preparation of encapsulates through...

B - Operations – Transporting – 01 – J

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B01J 13/16 (2006.01)

Patent

CA 2618894

The present invention relates to a process for the preparation of encapsulates, which process employs: ~ a pumpable emulsion comprising (i) a continuous phase containing a solvent and a matrix-forming solute dissolved in said solvent and (ii) a dispersed phase; ~ an extractant comprising supercritical, subcritical or liquefied gas; said solvent being substantially more soluble in the extractant than said matrix-forming solute and said process comprising the successive steps of: a. combining the pumpable emulsion with the extractant under mixing conditions; b. allowing the formation of particulate encapsulates in which the dispersed phase is encased in a solid matrix of the matrix-forming solute; c. collecting the encapsulates and separating them from the extractant. The present processes is particularly suitable for producing particles containing active ingredients that are very sensitive, e.g. ingredients whose activity is adversely affected by exposure to oxygen, light, moisture, heat and/or friction.

La présente invention concerne un procédé de préparation de produits d'encapsulation faisant appel à une émulsion pompable renfermant (i) une phase continue contenant un solvant et un soluté de formation de matrice dissous dans ledit solvant et (ii) une phase dispersée, ainsi qu'un agent d'extraction renfermant un gaz supercritique, sous-critique ou liquéfié, ledit solvant étant sensiblement plus soluble dans l'agent d'extraction que le soluté de formation de matrice. Ledit procédé consiste (a) à combiner l'émulsion pompable avec l'agent d'extraction dans des conditions de mélange, (b) à permettre la formation de produits d'encapsulation particulaires caractérisés en ce que la phase dispersée est enfermée dans une matrice solide constituée du soluté de formation de matrice, (c) à collecter les produits d'encapsulation et à les séparer de l'agent d'extraction. Les présents procédés sont particulièrement utiles pour produire des particules contenant des ingrédients actifs très sensibles, tels que des ingrédients dont l'activité est altérée par exposition à l'oxygène, à la lumière, à l'humidité, à la chaleur et/ou au frottement.

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