Process for the preparation of ergoline derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 457/06 (2006.01) A61K 31/48 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2106371

The invention provides a process for the preparation of ergoline derivatives of formula (I), the process comprising reacting an ergoline amide of formula (II) with an isocyanate of formula (III) in presence of a metal catalyst and of a phosphorus com- pound. The compounds of formula (I) are useful antiprolactinic and antiparkinson agents.

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