Process for the preparation of ethyl-n-(2,3 dichloro-6-...

Details Process for the preparation of ethyl-n-(2,3 dichloro-6-... Process for the preparation of ethyl-n-(2,3 dichloro-6-...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07C 205/12 (2006.01) C07C 227/18 (2006.01) C07C 229/14 (2006.01) C07D 491/147 (2006.01)

Patent

CA 2171073

The known blood platelet reducing agent Anagrelide is prepared via an improved process starting with commercially available 2,3-dichlorotoluene and involving novel intermediates represented by the formulas: Image (F) and Image (G) wherein Y is Br, Cl or I. Compound (G) is reacted with ethyl glycine to form the well-known intermediate ethyl-N-(2,3-dichloro-6-nitro benzyl) glycine which is then used following conventional process steps to form Anagrelide.

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