C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/26 (2006.01) C07H 17/04 (2006.01)
Patent
CA 2094009
An etoposide phosphate represented by the formula (1): Image is prepared by blocking -the hydroxyl groups of the saccharide moiety of etoposide with halogenoacetyl groups, thereafter phosphorylating -the 4'-position, and removing the halogenoacetyl groups from the obtained phosphate in the presence of an amine. This precess can give the objective etoposide phosphate in a higher yield than that of the prior art to enable the industrial mass-production thereof.
Miyazawa Yoshinobu
Ohkawa Kouichi
Sato Hitoshi
Tomiyoshi Noriko
Yoshikawa Hiroshi
Fetherstonhaugh & Co.
Nippon Kayaku Kabushiki Kaisha
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