Process for the preparation of fludarabine phosphate from...

Details Process for the preparation of fludarabine phosphate from... Process for the preparation of fludarabine phosphate from...

C - Chemistry, Metallurgy

07

H

C07H 19/19 (2006.01) C07H 19/16 (2006.01) C07H 19/20 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2149117

ABSTRACT OF THE DISCLOSURE A process for the production of fludarabine or flu- darabine phosphate is provided, wherein the nucleoside guanosine or a suitable derivative is employed as the starting material. The guanosine starting material is subjected to (a) conversion of the 6-keto group into a 6-amino group, (b) conversion of the 2-amino group to a 2-fluoro group, and (c) conversion of the ribofuranosyl moiety to an arabinofuranosyl moiety. Steps (a), (b), and (c) can be performed individually or concomitantly and in any sequence.

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