Process for the preparation of fluorosteroids

Details Process for the preparation of fluorosteroids Process for the preparation of fluorosteroids

C - Chemistry, Metallurgy

07

J

C07J 71/00 (2006.01) C07J 75/00 (2006.01)

Patent

CA 2348223

Described herein is a process for the preparation of 6.alpha.-fluorosteroids of formula (I), in which R is chosen from H, OH and an alkyl group with from 1 to 4 carbon atoms and R' is a carboxyalkyl group with from 1 to 4 carbon atoms in the alkyl chain, comprising the selective fluorination at the 6 .alpha.-position (see formula I and III) by treatment of the compound of formula (III), wherein R and R' are as defined above, with an electrophilic fluorinating agent.

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