C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/242.5
C07D 471/04 (2006.01)
Patent
CA 1301157
960-105 PROCESS FOR THE PREPARATION OF FUSED PYRIDINE COMPOUNDS ABSTRACT 2-Amino-4 hydroxy-6-[2-(4-carboxyphenyl)alk-1-en- 1-yl]pyrido[2,3,-d]pyrimidines and 2-amino-4-hydroxy-6- [2-(4-carboxyphenyl)alk-1-yn-1-yl]pyrido[2,3-d]pyrimi- dines are prepared through the reaction of a halo- aromatic compound and an unsaturated compound in the presence of a palladium catalyst. The products are chemical intermediates for the preparation of antineo- plastic agents. A typical embodiment is the reaction of a protected 2-amino-4-hydroxy-6-ethynylpyrido[2,3-d]pyrimidine and an ester of 4-iodobenzoic acid.
549572
Taylor Edward C.
Wong George S.k.
Gowling Lafleur Henderson Llp
Trustees Of Princeton University (the)
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