C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 231/10 (2006.01) C07C 233/08 (2006.01) C07D 221/20 (2006.01)
Patent
CA 2570461
The present invention relates to a process for the preparation of gabapentin and, more in particular, to a method of synthesis of 1,1-cyclohexane acetic acid monoamide, an intermediate used in the preparation of gabapentin, comprising the basic hydrolysis reaction of .alpha.,¬-diaminocarbonyl- .beta.,.beta.-pentamethylene glutarimide.
La présente invention concerne un procédé pour la préparation de gabapentine et, plus particulièrement, une méthode de synthèse de monoamide de l'acide 1,1-cyclohexane acétique, intermédiaire utilisé dans la préparation de gabapentine, faisant appel à la réaction d'hydrolyse basique d'a,.alpha.'-diaminocarbonyl-ß,ß-pentaméthylène glutarimide.
Arrighi Katiuscia
Cannata Vincenzo
Corcella Francesco
Paiocchi Maurizio
Soriato Giorgio
Riches Mckenzie & Herbert Llp
Zach System S.p.a.
Zambon Group S.p.a.
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