Process for the preparation of galanthamine hydrobromide

C - Chemistry – Metallurgy – 07 – D

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C07D 491/06 (2006.01)

Patent

CA 2592288

A process for the purification of galanthamine (I) comprising precipitation of galanthamine hydrobromide from a mixture of alkaloids obtained from a plant of the Amaryllidaceae family containing galanthamine, treatment of the hydrobromide with alkali, extraction and crystallization of galanthamine with a solvent of general formula (II), in which R1 is hydrogen or methyl and R2 is selected from n-butyl, isobutyl, sec-butyl and t-butyl. The resulting pure galanthamine can be conveniently used for the preparation of galanthamine hydrobromide.

La présente invention décrit un procédé de purification de la galantamine (I), qui comprend la précipitation du bromhydrate de galantamine à partir d'un mélange d'alcaloïdes provenant d'une plante de la famille Amaryllidaceae et contenant de la galantamine, le traitement dudit bromhydrate avec une base, l'extraction et la cristallisation de la galantamine à l'aide d'un solvant de formule générale (II), où R1 est un atome d'hydrogène ou un groupement méthyle, et R2 est sélectionné au sein du groupe constitué par le n-butyle, l'isobutyle, le sec-butyle et le t-butyle. La galantamine pure ainsi obtenue peut être employée de façon efficace dans la synthèse de bromhydrate de galantamine.

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