Process for the preparation of gestodene

Details Process for the preparation of gestodene Process for the preparation of gestodene

C - Chemistry, Metallurgy

07

J

C07J 1/00 (2006.01) C07J 21/00 (2006.01)

Patent

CA 2157076

Process for preparing Gestodene from (-)estra-1,3,5(10),8-tetraen-3- methoxy-18-methyl-17.beta.-hydroxy, comprising the following steps: a) hydrogenation of the double bond in 8(Li in liquid NH3 in presence of aniline); b) hydrogenation of a double bond of the aromatic ring (Li in liquid NH3 in presence of ter.butanol); c) hydrolysis of the methoxyl in 3 with introduction of a ketonic group and transposition of the double bond from 5-10 to 4-5; d) conversion of the ketonic group in 3 to acetalic group and transposition of the double bond from 4-5 to 5-6 (or 5-10); e) oxydation of the hydroxyl in 17 to a ketonic group; f) formation of a double bond in 15-16 by oxidation with Pd(II) acetate after transformation to sililenolether; g) ethynylation in position 17 with Li acetilide; h) hydrolysis of the acetalic group of position 3.

Affiliated with

Also associated with

Rating

Process for the preparation of gestodene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of gestodene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of gestodene will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1524450