Process for the preparation of glycidyl ethers

Details Process for the preparation of glycidyl ethers Process for the preparation of glycidyl ethers

C - Chemistry, Metallurgy

07

D

C07D 303/23 (2006.01) C07D 301/00 (2006.01) C07D 303/22 (2006.01) C07D 303/34 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01)

Patent

CA 2263267

The present invention is directed to a process for preparation of a glycidyl ether which is characterized by reacting an epoxy compound of the formula (see formula 1) wherein X is halogen or sulfonyloxy in the presence of a fluoride salt, with an alcohol. According to the above method, glycidyl ethers or their optically active compounds important as intermediates for synthesis of medicines are easily obtained in good yield and especially the optionally active compounds are obtained with high optical purity.

Un procédé de préparation d'éthers glycidyliques se caractérise par la réaction d'un composé époxy représenté par la formule générale (1) avec un alcool en présence d'un sel de fluor, formule dans laquelle X représente halogéno ou sulfonyloxy. Le procedé permets de préparer des éthers glycidyliques et leurs isomères optiques utiles en tant qu'intermédiaires dans la synthèse de médicaments à haut rendement par des moyens simples et faciles à mettre en oeuvre, les isomères optiques préparés par le procédé présentant une grande pureté optique.

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