Process for the preparation of glycine-conjugated bile acids...

Details Process for the preparation of glycine-conjugated bile acids... Process for the preparation of glycine-conjugated bile acids...

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/575 (2006.01) C07J 9/00 (2006.01)

Patent

CA 2092218

Abstract A process for the preparation of glycine-conjugated bile acids as per general formula (I): Y-NH-CH2-COOH (I) wherein Y is the acyl radical of a bile acid selected from the group consisting of ursodeoxycholic, chenodeoxycholic, lithocholic, 3.alpha.-7.beta.- 12.alpha.-tri-hydroxycholanic, 3.alpha.-7.beta.-dihydroxy-12-ketocholanic, deoxycholic, dehydrocholic, iodeoxycholic, iocholic acids and relative compositions for hepatic insufficiency treatment, containing the abovesaid acids as active ingredients, in continuation with suitable excipients and/or diluents.

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