Process for the preparation of glycoloylanilides

Details Process for the preparation of glycoloylanilides Process for the preparation of glycoloylanilides

C - Chemistry, Metallurgy

07

C

C07C 235/16 (2006.01) C07C 209/26 (2006.01) C07C 209/36 (2006.01) C07C 231/02 (2006.01) C07C 231/12 (2006.01) C07C 237/42 (2006.01) C07C 253/30 (2006.01) C07C 255/60 (2006.01) C07C 303/40 (2006.01) C07C 311/46 (2006.01)

Patent

CA 2147382

- 1 - Abstract Process for the preparation of glycoloylanilides The pre ent invention relates to a process for the preparation of glycoloylanilides of the formula (G) Image (G) which involves reacting a nitrobenzene of the formula (A) with hydrogen and, if desired, with a carbonyl compound of the formula (B), in the presence of a catalyst which comprises noble metal and of a solvent, in accordance with reaction equation (1) Image (1) (A) (B) (C) separating off the catalyst and reacting the compound of the formula (C) with chloroacetyl chloride, in accordance with reaction equation (2) - 2 - Image (2) (C) (D) to give a compound of the formula (D), reacting this with a benzyl alcohol of the formula (E), and with a base, in accordance with reaction equation (3) Image (3) (D) (E) (F) or reacting the compound of the formula (C) with an O- benzylglycoloyl chloride of the formula (R), in accord- ance with reaction equation (4) Image (4) (C) (K) (F) and reacting the O-benzylglycoloylanilide of the formula (F), in the presence of a catalyst which comprises noble metal, with hydrogen, in accordance with reaction equa- tion (5) - 3 - Image (5) (F) (G) (H) to give the glycoloylanilide of the formula (G). The present invention also relates to new O-benzylglycoloyl- anilides of the formula (F) and to a process for their preparation.

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