C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/79 (2006.01) C07D 213/00 (2006.01) C07D 213/02 (2006.01) C07D 213/04 (2006.01) C07D 213/60 (2006.01) C07D 213/78 (2006.01) C07D 213/803 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/00 (2006.01)
Patent
CA 2245080
The invention relates to a process for the preparation of heteroarylcarboxylic amides and esters of formula I (see formula I) in which A1 through A5, R1, Hal and X one or two of the groups A1, A2, A3, A4 and A5 represent a nitrogen atom and the other groups each independently represent CR3, Hal represents a halogen atom, X represents oxygen or NR2, R1 represents an optionally substituted alkyl, aryl, heteroaryl or cycloalkyl group, R2 represents a hydrogen atom or an alkyl group, or R1 and R2 together with the interjacent ring form a heterocyclic group, and R3 each independently represent a hydrogen atom or an alkyl group, which comprises: heating a mixture consisting essentially of heteroaryltrichloromethane compound of formula II, (see formula II) in which A1 through A5 and Hal are as hereinbefore defined, and 1.0 to 1.5 equivalents of concentrated sulfuric acid, and reacting the resulting intermediate product with an alcohol or amine of formula III HXR1 III optionally in the presence of a diluent and/or a base.
Brink Monika
Heinz Willi
Knell Marcus
Wevers Jan Hendrik
American Cyanamid Company
Basf Aktiengesellschaft
Smart & Biggar
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