Process for the preparation of heterocyclic compounds

Details Process for the preparation of heterocyclic compounds Process for the preparation of heterocyclic compounds

C - Chemistry, Metallurgy

07

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260/388, 260/291

C07D 307/54 (2006.01) C07D 213/32 (2006.01) C07D 213/56 (2006.01) C07D 213/68 (2006.01) C07D 213/86 (2006.01) C07D 233/54 (2006.01) C07D 277/26 (2006.01) C07D 307/52 (2006.01) C07D 333/24 (2006.01)

Patent

CA 1125298

PROCESS OF PRODUCING HETEROCYCLIC COMPOUNDS ABSTRACT Process of producing heterocyclic compounds shown by the formula Image wherein Het represents a 5-membered or 6-membered heterocyclic group which may have substituent(s); z represents sulfur atom or oxygen atom; X represents oxygen atom or the unsubstituted or substituted imino group shown by N-R1 (wherein R1 is hydrogen atom a lower alkyl group, a cyano group, an unsubstituted or alkyl substituted carbamoyl group, an unsubstituted or lower alkyl sub- stituted thiocarbamoyl group, or a lower alkanoylamino group); Y represents hydrogen atom, a lower alkyl group which may have sub- stituent(s), a cycloalkyl group of 3-6 carbon atoms, a lower alkenyl group, a lower alkynyl group, an aryl group which may have substituent(s), an aralkyl group which may have substltuent(s), a hydroxyl group, a cyano group, a carbamoyl group, an amidino group, an alkanoyl group which may have been substituted by halo- gen atom(s), an alkanoylamino group, an arylcarbonylamino group, an alkylamino group, an arylamino group, an arylsulfamoyl group, a lower alkoxycarbamoyl group, or an oxamoylamino group; and m and n represent an integer of 1-3; when X is N-R1, said X and Y may combine with each other to form a 5-membered or 6-membered heterocyclic ring containing 2-3 nitrogen atoms which may have substituent(s), and the pharmacologically acceptable acid addition salts thereof. The compounds of this invention are useful as gastric acid secretion inhibitors.

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