Process for the preparation of heterocyclylphenylformamidines

C - Chemistry – Metallurgy – 07 – D

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C07D 233/54 (2006.01) C07D 231/02 (2006.01) C07D 233/06 (2006.01) C07D 277/20 (2006.01) C07D 277/22 (2006.01) C07D 285/08 (2006.01)

Patent

CA 1247108

Abstract New process for the preparation of heterocyclylphenylformamidines of general formula I (I) Image wherein B represents a guanidino group or a hydrogen atom; R represents a linear or branched alkyl group which may optionally contain one heteroatom such as oxygen or nitrogen atom, an alkenyl group, a cycloalkyl or cycloaliphatic alkyl group having 3 to 6 carbon atoms; R1 represents a hydrogen atom, a C1-3 alkyl or alkoxy group or halogen atom; Het represents a substituted or unsubstituted five-membered heterocyclic ring containing from 1 to 3 heteroatoms; tautomers thereof and acid addition salts of the aforesaid compounds, which comprises desulphurizing the corresponding thioureas.

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