Process for the preparation of high purity sunitinib and its...

Details Process for the preparation of high purity sunitinib and its... Process for the preparation of high purity sunitinib and its...

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01)

Patent

CA 2724310

The present invention relates to an improved process for the preparation of N- [2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1, 2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3- carboxamide - Sunitinib base of formula (I) and its pharmaceutically acceptable malate salt of formula (I(a)).

La présente invention porte sur un procédé perfectionné de préparation du N-[2-(diéthylamino)éthyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)méthyl]-2,4-diméthyl-1H-pyrrole-3-carboxamide - Sunitinib base de formule I et de son sel malate de formule I(a) pharmaceutiquement acceptable.

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