Process for the preparation of homoserine lactones

Details Process for the preparation of homoserine lactones Process for the preparation of homoserine lactones

C - Chemistry, Metallurgy

07

D

C07D 307/33 (2006.01)

Patent

CA 2060855

HOE 91/F045 Abstract of the disclosure A process for the preparation of homoserine lactones .alpha.-Amino-.gamma.-butyrolactones (homoserine lactones) are a central structural element in many biologically active compounds. The known syntheses for the preparation of optically active homoserine lactones from D- or L-methio- nine and D- or L-aspartic acid derivatives have disad- vantages. Homoserine lactones I and their salts can be prepared enantioselectively according to the invention by catalytic hydrogenation of aldehydes II (I) Image Image (II) where R in the formulae is hydrogen, alkyl, alkenyl, alkynyl, it being possible for the aforementioned three radicals to have hetero atoms in the chain, alkyl- carbonyl, alkoxycarbonyl, alkylsulfonyl, benzyl, benzyloxycarbonyl, aryloxycarbonyl or arylsulfonyl, it being possible for the four last-mentioned radicals to be optionally substituted in the aryl moiety.

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