C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/128.2
C12P 21/04 (2006.01) C07K 14/62 (2006.01)
Patent
CA 1190496
Abstract of the disclosure: The invention provides a process for the preparation of human insulin or the derivatives thereof from pig insulin or the derivatives thereof, which comprises re- acting pig insulin or a derivative thereof at a pH below its isoelectric point with an excess of a threonine ester or one of its derivatives in the presence of trypsin or a trypsin-like enzyme, and optionally splitting off the ester group thereafter.
394297
Ludwig Jurgen
Obermeier Rainer
Seipke Gerhard
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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