Process for the preparation of hydroxy acids

Details Process for the preparation of hydroxy acids Process for the preparation of hydroxy acids

C - Chemistry, Metallurgy

12

P

195/129, 260/241

C12P 7/42 (2006.01) C07C 51/367 (2006.01) C07D 223/16 (2006.01) C07K 5/078 (2006.01) C12P 41/00 (2006.01)

Patent

CA 1336081

The invention relates to a preferably continuous process for the prepara- tion of R- or S-2-hydroxy-4-phenylbutyric acid in very high enantiomeric purity, which comprises reducing 2-oxo-4-phenylbutyric acid with the enzyme D-lactate dehydrogenase from Staphylococcus epidermidis or with the enzyme L-lactate dehydrogenase from bovine heart, respectively, in the presence of NAD(H) and formate or ethanol and formate dehydrogenase or alcohol dehydrogenase, respectively. R-2-hydroxy-4-phenylbutyric acid is a valuable intermediate in the preparation of ACE inhibitors or their precursors.

601534

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