Process for the preparation of imidazobenzodiazepines

Details Process for the preparation of imidazobenzodiazepines Process for the preparation of imidazobenzodiazepines

C - Chemistry, Metallurgy

07

D

260/239.4

C07D 487/04 (2006.01) A01N 43/90 (2006.01) C07C 45/51 (2006.01) C07C 47/14 (2006.01) C07D 233/54 (2006.01)

Patent

CA 1126269

RAN 4008/302 Abstract Imidazobenzodiazepines of the formula Image I wherein X and Y, independently, represent hydrogen, halogen or trifluoromethyl, and pharmaceutically acceptable acid addition salts thereof are prepared by a novel process which comprises converting a compound of the general formula Image wherein X and Y have the meaning indicated above, into the corresponding compound of formula I by treatment with a lower alkylamine or a hydrazine or by acid or base hydrolysis, and if desired, converting a compound thus obtained into a pharmaceutically acceptable acid addition salt thereof. The compounds of the formula I are known and useful as sedatives, anxiolytics, muscle relaxants and anti- convulsants.

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