Process for the preparation of imidazopyridine derivatives...

Details Process for the preparation of imidazopyridine derivatives... Process for the preparation of imidazopyridine derivatives...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) C07C 63/72 (2006.01) C07C 65/105 (2006.01) C07C 69/732 (2006.01) C07C 69/76 (2006.01) C07C 309/63 (2006.01) C07C 323/12 (2006.01) C07C 323/66 (2006.01) C07D 213/73 (2006.01) C07D 213/75 (2006.01) C07D 263/10 (2006.01) C07D 263/12 (2006.01) C07D 263/14 (2006.01) C07D 307/70 (2006.01) C07D 309/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07F 7/08 (2006.01)

Patent

CA 2128014

ABSTRACT The present invention provides an industrially advantageous process for preparing a 2-alkyl-3- (biphenyl-4-yl)methyl-3H-imidazo[4.5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin II receptor useful as an antihypertensive drug, a biphenyl derivative which is a precursor of the substituent of the pyridine derivative, a process for the preparation thereof, and an intermediate useful for the preparation of the biphenyl derivative: Image (II) The 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo- [4,5-b]pyridine derivative can be prepared in a high yield according to the present invention from a 2- amino-5-halogeno-3-nitropyridine derivative through amidation, N-alkylation and reductive cyclization. The halogen atom introduced at the 5-position as a - 292 - protective group against nitration can be eliminated simultaneously in the step which is conducted thereafter. Thus, this process is industrially advantageous. Further, the biphenyl derivative of the present invention is excellent in reactivity and purity of the product, thus being an intermediate suitable for the - 293 -

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