Process for the preparation of intermediates useful in the...

C - Chemistry – Metallurgy – 07 – C

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C07C 67/30 (2006.01) C07C 69/67 (2006.01) C07C 69/675 (2006.01) C07C 69/708 (2006.01) C07C 69/716 (2006.01) C07C 69/732 (2006.01) C07C 69/738 (2006.01) C07C 227/32 (2006.01) C07C 229/22 (2006.01) C07C 235/06 (2006.01) C07C 235/74 (2006.01) C07C 247/12 (2006.01) C12P 7/62 (2006.01)

Patent

CA 2448917

The invention relates to synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or N(CH3)OCH3, Ra is a hydroxy-protecting group, and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further intermediates and methods for their preparation by Friedel-Crafts acylation.

Cette invention concerne des procédés de synthèse pour la préparation de dérivés de statine, qui font intervenir un intermédiaire clé de formule (I), dans laquelle X est halogène, acyloxy, hydrocarbyloxy activé, hydrocarbylthio activé ou N(CH¿3?)OCH¿3?, R¿a? est un groupe protecteur hydroxy, et R¿b? est un groupe protecteur carboxy. L'invention concerne également, comme pour le composé de formule (I), d'autres intermédiaires ainsi que leur procédés de préparation par acylation Friedel-Crafts.

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