Process for the preparation of iodinated contrast agent

Details Process for the preparation of iodinated contrast agent Process for the preparation of iodinated contrast agent

C - Chemistry, Metallurgy

07

C

C07C 231/02 (2006.01)

Patent

CA 2743079

The present invention relies on a process for the preparation of non ionic iodinated contrast agents and, in more details, it relates to a process for the preparation of Iopamidol in high yields and with a high degree of purity. In more details, the invention discloses a process for the preparation of a compound of formula (III) comprising the 5 condensation reaction a com-pound of formula (II) with 2-amino-1,3-propandiol, being said reaction carried out in an aprotic dipolar solvent and in the pres-ence of an alkaline or alkaline rare earth metal oxide or hydroxide.

La présente invention concerne un procédé de synthèse d'agents de contraste iodés non ioniques et, de façon plus détaillée, elle concerne un procédé de synthèse de lIopamidol avec un rendement et un niveau de pureté élevés. De façon plus détaillée, la présente invention concerne un procédé de synthèse d'un composé de formule (III) comportant la réaction de 5-condensation d'un composé de formule (II) avec le 2-amino-1,3-propandiol, ladite réaction étant mise en uvre dans un solvant dipolaire aprotique en présence d'un oxyde ou d'un hydroxyde de métal alcalin ou alcalino-terreux rare.

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