C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 213/04 (2006.01) C07C 231/12 (2006.01) C07C 231/14 (2006.01) C07C 233/65 (2006.01) C07C 237/30 (2006.01) C07C 237/42 (2006.01) C07D 303/36 (2006.01) C07C 233/18 (2006.01) C07C 233/22 (2006.01) C07C 237/46 (2006.01)
Patent
CA 2280235
The invention provides a process for the production of a 2,3- dihydroxypropylamino compound, said process comprising the reaction steps of: (i) obtaining an allylamino compound; (ii) epoxidizing said allylamino compound to yield an epoxypropylamino compound; and (iii) hydrolysing said epoxypropylamino compound to yield a 2,3-dihydroxypropylamino compound. This process may be used to produce simple 2,3-dihydroxypropylamino compounds such as APD or complex ones such as BAPD (an intermediate in the production of iohexol).
L'invention concerne un procédé de préparation d'un composé 2,3-dihydroxypropylamino, lequel procédé comprend les étapes suivantes: (i) obtention d'un composé allylamino; (ii) époxydation dudit composé allylamino de manière à obtenir un composé époxypropylamino; et (iii) hydrolyse dudit composé époxypropylamino de manière à obtenir un composé 2,3-dihydroxypropylamino. Ce procédé peut être utilisé pour obtenir des composés 2,3-dihydroxypropylamino simples tels que ADP ou des composés complexes tels que BAPD (produit intermédiaire dans la préparation de l'iohexol).
Lane David Redick
Vasilevskis Janis
Fetherstonhaugh & Co.
Nycomed Imaging As
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