Process for the preparation of isoquinoline derivatives

Details Process for the preparation of isoquinoline derivatives Process for the preparation of isoquinoline derivatives

C - Chemistry, Metallurgy

07

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260/273, 260/296

C07D 471/04 (2006.01) C07D 213/82 (2006.01) C07D 401/06 (2006.01) C07D 413/04 (2006.01) C07D 471/14 (2006.01) C07F 1/02 (2006.01) C07F 3/02 (2006.01) C07F 13/00 (2006.01)

Patent

CA 1335203

Disclosed is a process for the preparation of isoquinoline derivatives useful as anti-tumoral and anti- leukemic agents, which are of the general formula: Image (I) in which: - R1 and R'1 which are identical or different, each is selected from hydrogen and C1-4 alkyl; - X is selected from nitrogen and C-OR2 in which R2 is selected from C1-4 alkyl and benzyl, - Am represents an amino group substituted or not by a group of the formula: Image in which R3 and R4, identical or different, each is selected from hydrogen and an alkyl radical having from 1 to 6 carbon atoms, R5 is selected from hydrogen and an alky radical having from 1 to 6 carbon atoms and n represents a value of from 1 to 10. The process comprises four steps, wherein use is made of organo-lithium compounds or related compounds as synthetic intermediates.

591161

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