Process for the preparation of l-.alpha.-aminoacids

C - Chemistry – Metallurgy – 12 – P

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195/134, 260/516

C12P 13/04 (2006.01) C12P 17/10 (2006.01) C12P 41/00 (2006.01)

Patent

CA 1239607

"PROCESS FOR THE PREPARATION OF L-.alpha.-AMINOACIDS" Abstract of the Disclosure Process for the preparation of L-.alpha.-aminoacids Image (I) wherein R is an aromatic, substituted aromatic, aliphat ic or substituted aliphatic group, in which process: a) An N-carbamyl-.alpha.-aminoacid compound of formula: Image (II) wherein R has the above-specified meaning and in the form of D-N-carbamyl-.alpha.-aminoacid and L-N-carbamyl-.alpha.- aminoacid id contacted, in a liquid reaction mixture, and at a pH of form 6,0 to 7,0 and at a temperature of from 20°C to 40°C, with an enzyme to give a com- pound formula Image (III) wherein R has the above-specified meaning, in the 2. of D-hydantoin, and a compound of formula Image (IV) where R has the above-indicated meaning, in the form of L-N-carbamyl-.alpha.-aminoacid; b) D-hydantoin is separated from the reaction mixture, and is hydrolyzed and racemized to D-N-carbamyl-.alpha.-a minoacid, and L-N-carbamyl-.alpha.-aminoacid; c) L-N-carbamyl-.alpha.-aminoacid is trasformed into corres- ponding L-.alpha.-aminoacid; d) L-.alpha.-aminoacid is separated and recovered from the reaction mixture.

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