Process for the preparation of lactones

Details Process for the preparation of lactones Process for the preparation of lactones

C - Chemistry, Metallurgy

07

D

260/355.1, 260/3

C07D 313/00 (2006.01)

Patent

CA 1075247

ABSTRACT OF THE DISCLOSURE An improved process for producing a large ring lactone which comprises subjecting a hydroxy acid to intramolecular condensation by the use of a 1-substituted-2-halopyridinium salt or a 1-substituted-2- haloquinolinium salt as a condensing agent in the presence of an acid capter in an anhydrous organic solvent. According to this process, various lactomes and even complex ones such as macrolides may be obtained in good yields.

261846

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