Process for the preparation of liposomal medicaments

Details Process for the preparation of liposomal medicaments Process for the preparation of liposomal medicaments

A - Human Necessities

61

K

167/153

A61K 9/10 (2006.01) A61K 9/127 (2006.01)

Patent

CA 1177396

ABSTRACT OF THE DISCLOSURE Associates of at least one amphiphilic bilayer-forming substance and a solubilizing agent are formed in an aqueous phase. The bilayer- forming substance itself can be a pharmaceutical substance, or pharmaceuti- cal substances and/or pharmaceutical auxiliaries may be added. The novel process for preparing liposomal medicaments from such aqueous phase com- prises increasing the molar ratio of the bilayer-forming substance to the solubilizing agent in such associates, at a rate which is essentially con- stant in time and location and which is sufficiently high for the associ- ates to combine to form liposomes, essentially all of which have a pre- determined number of double layers, and which have a predetermined essentially homogeneous size. The liposomes thereby achieve a predefined, virtually homogeneous size.

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