Process for the preparation of midazolam

Details Process for the preparation of midazolam Process for the preparation of midazolam

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07D 235/00 (2006.01) C07D 243/00 (2006.01)

Patent

CA 2374127

The present invention provides a process for the synthesis of Midazolam of formula (I) from a compound of formula (II), using thermodynamic, basic workup conditions. Additional steps to isolate the pure bulk product follow.

La présente invention concerne un procédé de synthèse de Midazolam représenté par al formule générale (I) à partir d'un composé représenté par la formule spécifique (II), et ce, dans des conditions d'investigation de base de la thermodynamique. Ce procédé est complété par des opérations ultéieures visant à isoler le produit pur.

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