C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/329.3
C07D 333/20 (2006.01)
Patent
CA 1329212
ABSTRACT This invention relates to a process for the preparation of N-(2-chlorobenzyl)-2-(2-thienyl)- ethylamine, a useful intermediate in the synthesis of ticlopidine which is a platelet aggregation inhibitor. According to the invention N-(2-chlorobenzyl)-2-(2- thienyl)-ethylamine is prepared by reaction of 2- thiophene acetonitrile with 2-chlorobenzylamine and hydrogen in the presence of a hydrogenation catalyst. This process is particularly advantageous since it ensures good yields while being unexpensive.
584974
Robic
Sanofi-Aventis
LandOfFree
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