Process for the preparation of n-arylhalopyrrolidones

Details Process for the preparation of n-arylhalopyrrolidones Process for the preparation of n-arylhalopyrrolidones

C - Chemistry, Metallurgy

07

D

260/324

C07D 207/26 (2006.01) C07D 207/273 (2006.01)

Patent

CA 1216298

ABSTRACT OF THE DISCLOSURE Intramolecular cyclization of an .alpha.-halogen-N-2-alkenylamide conducted in the presence of a copper-containing catalyst and a primary or secondary aliphatic amine produces the N-arylhalopyrrolidones of the formula Image wherein X is selected from the group consisting of hydrogen, chlorine, bromine and fluorine; Y is selected from the group consisting of hydrogen, chlorine, bromine and fluorine; Z is selected from the group consisting of chlorine and bromine; R1 is selected from the group consisting of hydrogen and C1-C4 alkyl; R2 is selected from the group consisting of hydrogen, C1-C4 alkyl, acetyl, chlorine, bromine, fluorine, iodine, trifluoromethyl, nitro, cyano, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, trifluoromethylthio, trifluoromethylsulfinyl, trifluoro- methylsulfonyl, pentafluoropropionamido, and 3-methylureido; and R3 is selected from the group consisting of hydrogen, C1-C4 alkyl, chlorine, and trifluoromethyl.

456705

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