C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/08 (2006.01) A61K 31/5386 (2006.01) A61K 31/5395 (2006.01)
Patent
CA 2610089
There is provided a process for the preparation of a sulfonic acid salt of formula I, or a solvate thereof, which process comprises hydrogenating a sulfonic acid salt of formula II,. or a solvate thereof; in the presence of a solvent system consisting essentially of water, a C3-5 secondary alkyl alcohol and no more than 15% v/v of another organic solvent, wherein the sulfonic acid salt of formula I is optionally, without isolation, converted to a compound of formula IX, or a pharmaceutically-acceptable derivative thereof, wherein R1, R2, R3, R6, R7, R8, A, B and D have meanings given in the description.
La présente invention concerne un procédé de synthèse d'un sel d'acide sulfonique de formule I ou d'un solvate dudit sel, ledit procédé comprenant l'hydrogénation d'un sel d'acide sulfonique de formule II ou d'un solvate dudit sel ; en présence d'un système solvant essentiellement constitué d'eau, d'un alcanol secondaire en C3-C5 et d~au maximum 15 % en volume d'un autre solvant organique, ledit sel d'acide sulfonique de formule I étant éventuellement, sans isolement intermédiaire, converti en un composé de formule IX, ou d'un dérivé de qualité pharmaceutique dudit composé, où R1, R2, R3, R6, R7, R8, A, B et D sont tels que définis dans la description de l'invention.
Cladingboel David
Ensor Gareth
Astrazeneca Ab
Fetherstonhaugh & Co.
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