Process for the preparation of neotame

Details Process for the preparation of neotame Process for the preparation of neotame

C - Chemistry, Metallurgy

07

K

C07K 5/075 (2006.01) A23L 1/236 (2006.01) C07K 5/072 (2006.01)

Patent

CA 2343114

The invention relates to an improved process for the preparation of neotame by successively: (a) subjecting a mixture of N-benzyloxycarbonyl-L-.alpha.- aspartyl-L-phenylalanine-1-methyl ester and 3,3-dimethylbutyraldehyde in solution to hydrogenation in a homogeneous methanolic solvent, in the presence of a hydrogenation catalyst; (b) separating the catalyst from the solution as a solid substance; (c) removing a portion, at least, of the organic part of the solvent through evaporation and optionally adding an amount of water before and/or during and/or after that evaporation and (d) separating the solid neotame formed, optionally after cooling of the system thus obtained, from the remaining liquid and drying it.

L'invention concerne un procédé amélioré de préparation de néotame, le procédé consistant successivement: (a) à soumettre un mélange d'un ester de N-benzyloxycarbonyl-L-.alpha.-aspartyl-L-phénylalanine-1-méthyl et de 3,3-diméthylbutyraldéhyde en solution à une hydrogénation dans un solvant dans le méthanol homogène, en présence d'un catalyseur d'hydrogénation; (b) à séparer le catalyseur de la solution sous forme de substance solide; (c) à retirer une partie, au moins, de la partie organique du solvant par évaporation et éventuellement à ajouter une quantité d'eau avant et/ou pendant et/ou après l'évaporation; et (d) à séparer le néotame solide formé, éventuellement après refroidissement du système obtenu, du liquide restant et à le sécher.

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