C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/273
C07D 471/04 (2006.01)
Patent
CA 1297107
Abstract The invention relates to a process for the pre- paration of new 2-(2-thienyl)imidazo(4,5-c)pyridine derivatives of the general formula Image wherein R1 denotes lower alkyl, R2 denotes hydrogen or methyl and n denotes 0 or 1, and pharmaceutically usable acid addition salts thereof, by reacting a thiophenecar- boxylic acid chloride of the general formula III with a diaminopyridine of the general formula IV of the descrip- tion to give an isomer mixture consisting of amides of the general formula Image V, wherein R1 and R2 are as defined in formula I, one of the symbols A and B denotes the =N atom and the other in each case denotes =CH-, then cyclizing the isomer mixture in the form of the hydrochlorides and, if appropriate, oxidizing a resulting compound of the formula I in which n denotes 0 to give a compound of the formula I in which n denotes 1 by treatment with organic peracids or hydrogen peroxide, and, if desired, converting the resulting com- pounds of the formula I into pharmaceutically usable salts. The new compounds have useful pharmacological proper- ties, in particular a strongly positively inotropic action, and can be used as active compounds for medicaments for the treatment of diseases of the heart and vessels, in particular myocardial insufficiency.
519580
Binder Dieter
Rovenszky Franz
Chemisch Pharma - Zeutische Forschungsgesellschaft M.b.h.
Riches Mckenzie & Herbert Llp
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