Process for the preparation of new derivatives of...

Details Process for the preparation of new derivatives of... Process for the preparation of new derivatives of...

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/36 (2006.01) A61K 31/505 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 501/06 (2006.01) C07D 501/20 (2006.01) C07D 501/28 (2006.01) C07D 501/34 (2006.01) C07D 501/46 (2006.01) C07D 277/20 (2006.01)

Patent

CA 1209126

ABSTRACT OF THE DISCLOSURE This invention concerns a process for the preparation of products with the formula : Image (1) in which COOA is an acidic radical, salt or ester, R1 represents a group: Image in which RA and RB are H or alkyl or form a cycloalkyl with the carbon with which they are bonded, R2 and R3 are H, alkyl or alkenyl, R4 and R5 are H, alkyl or alkenyl or form a ring with the nitrogen atom with which they are bonded. The said process consisting of causing amino- bromoethyl cepheme-3 carboxylate of tertiobutyl-4 S-oxide to react with an amino acid with the formula : Image followed, after elimination of the protector groups, by the reaction of the product obtained with a thiourea.

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