C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/314, 260/304
C07D 233/60 (2006.01) C07D 233/54 (2006.01) C07D 403/12 (2006.01)
Patent
CA 1186315
ABSTRACT OF THE DISCLOSURE New imidazole compounds and their salts endowed with analgesic, antipyretic and antiinflammatory activity are disclosed together with a process for their preparation. These compounds are compounds of the general formula (I) Image (I) wherein R1 is selected from the group comprising a straight or branched chain alkyl having from 1 to 10 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, aryl optionally substituted by halogen, alkyl having from 1 to 3 carbon atoms, alkoxy having from 1 to 3 carbon atoms, amino, acylamino having from 2 to 5 carbon atoms, arylalkyl optionally sub- stituted by halogen, alkyl having from 1 to 3 carbon atoms, alkoxy having from 1 to 3 carbon atoms, (imidazol-4-yl)-alkyl, acyl and aroyl, R2 and R3 are the same or different and each is selected from the group comprising hydrogen, halogen, hydroxyl, straight or branched chain alkyl having from 1 to 4 carbon atoms, alkoxyl having from 1 to 4 carbon atoms, alkylthio, alkylsulfonyl, or R2 and R3 together represent an aromatic ring condensed with phenyl, R4 is hydrogen, aryl optionally substituted by halogen, alkyl having from 1 to 3 carbon atoms, alkoxy having from 1 to 3 carbon atoms, amino, acylamino having from 2 to 5 carbon atoms, and a pharmaceutically acceptable acid addition salt thereof.
408135
Bella Davide Della
Carenzi Angelo
Chiarino Dario
Frigeni Viviana
Veneziani Carlo
Riches Mckenzie & Herbert Llp
Zambon S.p.a.
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